Quinolines and derivatives
Medchemexpress LLC B7-H2/ICOSLG protein, rat recombinant, C-His tagged | >95.0% | 500 UG
Recombinant rat B7-H2 (ICOSLG) protein expressed in HEK293 cells and purified for use in binding and functional assays. Supplied lyophilized with a C-terminal His tag, it is intended for research applications studying ICOS-ICOSLG interactions.
- Recombinant rat ICOS ligand expressed in HEK293 cells.
- C-terminal His tag for detection and purification.
- Supplied lyophilized from PBS, pH 7.4.
- Purity >95.0% by reducing SDS-PAGE.
- Sequence corresponds to residues E25-K261.
- Approximate molecular weight 40-60 kDa.
- Recommended reconstitution ≥100 μg/mL; store lyophilized at -20°C.
- Validated in ELISA with ED50 ≈ 89.92 ng/mL.
Medchemexpress LLC 9-(oxolan-2-yl)purin-6-amine | 17318-31-9 | MFCD00210216 | ≥98.0% | 205.22 g/mol | C9H11N5O | 200 MG
SQ22536 is a small-molecule adenylate cyclase inhibitor used in research to modulate cAMP signaling. It is provided as a powder and is characterized by CAS 17318-31-9, molecular formula C9H11N5O, and molecular weight 205.22 g/mol. The compound is suitable for laboratory-scale in vitro and in vivo studies with documented solubility and storage recommendations.
- Potent adenylate cyclase inhibitor for cAMP pathway studies.
- Suitable for in vitro and in vivo applications with established vehicle formulations.
- Soluble in DMSO and water at experimentally useful concentrations.
- Stable as a powder under cold storage with multi-year shelf life.
- Provided as an analytical standard for research use only.
Apexbio Technology LLC WAY-100635 162760-96-5 200mg
WAY-100635 (CAS 162760-96-5) is a highly selective antagonist of the serotonin 5-HT1A receptor In vitro studies show that WAY-100635 displaces the 5-HT1A radioligand [3H]8-OH-DPAT from rat hippocampal membranes with a pIC50 of 8 87 and acts as a potent antagonist in functional assays without agonist or partial agonist activity In ex vivo guinea pig ileum assays it effectively blocks 5-carboxamidotryptamine-induced 5-HT1A responses (pA2 9 71 at 0 3 nM) In vivo WAY-100635 counteracts 8-OH-DPAT-induced behavioral and thermoregulatory effects in rodents at subcutaneous doses as low as 0 003 0 01 mg/kg It is widely utilized in neuropharmacological research and neuroimaging as a SPECT/PET ligand to investigate 5-HT1A receptor function in psychiatric and neurological disorders
TARGETMOL CHEMICALS INC JH-RE-06 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POL(zeta). JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 uM; Kd=0.42 uM) which targets REV1 that interacts with the REV7 subunit of POL(zeta). JH-RE-06 also improves chemotherapy. purity: 99%
Apexbio Technology LLC LY2784544 1229236-86-5 200mg
LY2784544 (CAS 1229236-86-5) is a potent and selective ATP-competitive inhibitor of JAK2 tyrosine kinase exhibiting an IC50 of 3 nM It demonstrates 8-fold and 16-fold selectivity over JAK1 and JAK3 respectively In cellular assays LY2784544 effectively inhibits STAT5 phosphorylation in Ba/F3-TEL-JAK2 cells (IC50 0 191 nM) while displaying substantially reduced activity against JAK1 and JAK3-dependent STAT5 phosphorylation The compound suppresses proliferation and induces apoptosis in cells harboring the JAK2 V617F mutation In murine models it reduces tumor burden and strongly inhibits STAT5 phosphorylation in JAK2 V617F-driven cells LY2784544 is a valuable tool for studying JAK2-mediated signaling and myeloproliferative neoplasms
Medchemexpress LLC Cytochrome c (bovine heart) | 9007-43-6 | MFCD00130890 | 95.0% | 12,327 Da | 200MG
Cytochrome c (bovine heart) is a heme-containing mitochondrial protein provided as a lyophilized powder for research use. It functions in electron transport and is commonly used as a reagent or standard in biochemical assays of oxidative phosphorylation, electron-transfer reactions, and apoptosis research. The material is characterized by its protein sequence and heme prosthetic group and is supplied at ~95% purity.
- Heme-containing mitochondrial protein suitable for biochemical studies.
- Commonly used as a reagent or standard in electron transport and apoptosis assays.
- Provided as a lyophilized powder for convenient storage and handling.
- Purity approximately 95.0% as listed by the manufacturer.
- Available in multiple pack sizes, including a 200 mg pack.
- Identified by CAS number 9007-43-6 for reference and traceability.
TARGETMOL CHEMICALS INC Altrenogest 200MG
Also available in 1 mL, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Altrenogest (Allyltrenbolone)(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone. Purity 99.61%
Apexbio Technology LLC Diosmetin 520-34-3 200mg
Diosmetin (CAS 520-34-3) is a small molecule flavonoid that functions as an agonist of the aryl hydrocarbon receptor (AHR) a ligand-activated transcription factor involved in the regulation of xenobiotic-metabolizing enzymes In cell-based studies diosmetin dose-dependently increases AHR-mediated transcriptional activation including upregulation of CYP1A1 mRNA and enzymatic activity in MCF-7 cells The compound demonstrates inhibitory effects on CYP1A1 enzyme activity with an IC50 of approximately 30 nM in microsomal assays Diosmetin is utilized in biomedical research to study AHR activation CYP1 enzyme regulation and related cellular responses such as viability and gene expression changes
TARGETMOL CHEMICALS INC Cefotiam hydrochloride 200MG
Also available in 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Cefotiam hydrochloride (SCE-963 hydrochloride) is the hydrochloride salt form of cefotiam, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted. Purity 98.74%
Medchemexpress LLC CP 339818 (hydrochloride) | 478341-55-8 | 99.6% | 340.89 | 25 MG
CP 339818 hydrochloride is a non-peptide blocker for Kv1.3 and Kv1.4 channels. It also inhibits HCN channels and exhibits significantly weaker blocking effects on several other Kv channels. This compound selectively blocks Kv1.3, thereby inhibiting the activation process of human T cells, and is useful for studying the physiological functions of HCN and Kv channels.
- Kv1.3 channel blocker (IC50 = 200 nM).
- Kv1.4 channel blocker.
- Inhibits HCN channels (HCN1 and HCN4).
- Selectively inhibits human T cell activation.
- Suitable for studying physiological functions of HCN and Kv channels.
Medchemexpress LLC CP 339818 hydrochloride | 478341-55-8 | 99.6% | 340.89 g/mol | C21H25ClN2 | 5 MG
CP 339818 hydrochloride is a small-molecule, non-peptide ion-channel inhibitor used in electrophysiology and pharmacology research. It blocks Kv1.3 and Kv1.4 channels and inhibits HCN channels, making it useful for studying Kv- and HCN-mediated currents and T-cell activation.
- Non-peptide Kv1.3 and Kv1.4 channel blocker.
- Inhibits HCN channel isoforms with micromolar potency.
- High-purity white to off-white solid suitable for research use.
- Soluble in DMSO up to 62.5 mg/mL.
- Store sealed at 4°C; in solution, keep at -80°C (up to 6 months) or -20°C (up to 1 month).
- Molecular weight 340.89 g/mol; formula C21H25ClN2.
Medchemexpress LLC CP 339818 (hydrochloride) | 478341-55-8 | 99.6% | 340.89 | 1 MG
CP 339818 hydrochloride is a non-peptide blocker of Kv1.3 (IC50 = 200 nM) and Kv1.4 channels. It also inhibits HCN channels with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl-), respectively. The compound exhibits significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. It can be utilized for studying the physiological functions of HCN and Kv channels.
- Non-peptide Kv1.3 and Kv1.4 channel blocker.
- Inhibits HCN channels (HCN1 and HCN4).
- Selectively blocks Kv1.3, inhibiting human T cell activation.
- Useful for studying physiological functions of HCN and Kv channels.
- Suppresses human T cell activation.
- Effectively blocks remaining outward potassium current in Kv2.1⁻/⁻ β cells.
- Inhibitory effect on HCN1 and HCN4 is weakened in low-concentration Cl- internal solution and is voltage-dependent.
Medchemexpress LLC Quinidine (15% dihydroquinidine) | 56-54-2 | >98.36% | 10 G
Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. It acts as a potent, orally active, and selective cytochrome P450db inhibitor. Additionally, Quinidine is a K+ channel blocker with an IC50 of 19.9 μM and is capable of inducing apoptosis. This compound can also be utilized for malaria research.
- Antiarrhythmic agent.
- Potent, orally active, selective cytochrome P450db inhibitor.
- K+ channel blocker with an IC50 of 19.9 μM.
- Can induce apoptosis.
- Used for malaria research.
Medchemexpress LLC Quinine sulfate hydrate | 6119-70-6 | 99.97% | 409.48 | 25 G
Quinine sulfate hydrate is an orally active alkaloid extracted from cinchona bark, primarily used in anti-malarial studies. It also functions as a potassium channel inhibitor, inhibiting WT mouse Slo3 (KCa5.1) channel currents.
- Orally active alkaloid
- Extracted from cinchona bark
- Used in anti-malarial studies
- Potassium channel inhibitor
- Inhibits WT mouse Slo3 (KCa5.1) channel currents
- Inhibits DENV proliferation and reduces viral RNA/protein levels
- Shows tumor-suppressing effects